KMID : 1234520160110010017
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Korean Journal of Urogenital Tract Infection Inflammation 2016 Volume.11 No. 1 p.17 ~ p.24
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Infectious Complications after Prostate Biopsy: A Prospective Multicenter Prostate Biopsy Study
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Hwang Eu-Chang
Yu Ho-Song Jung Seung-Il Kwon Dong-Deuk Lee Sun-Ju Kim Tae-Hyoung Chang In-Ho Yoon Ha-Na Shim Bong-Suk Kim Kwang-Hyun Lee Dong-Hyun Huh Jung-Sik Lim Dong-Hoon Jo Won-Jin Min Seung-Ki Lee Gil-Ho Kim Tae-Hwan Lee Seo-Yeon Yang Seung-Ok Chung Jae-Min Lee Sang-Don Han Chang-Hee Bae Sang-Rak Choe Hyun-Sop Lee Seung-Ju Chung Hong Na Yong-Gil Yang Seung-Woo Kim Young-Ho Kim Tae-Hyo Cho Won-Yeol Han June-Hyun Cho Yong-Hyun Ha U-Syn Park Heung-Jae
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Abstract
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Purpose: Recent studies have highlighted an increasing trend of infectious complications due to fluoroquinolone-resistant organisms among men undergoing transrectal prostate biopsy. This study evaluated the current incidence of infective complications after trans-rectal prostate biopsy for identification of risk factors in Korean men who received fluoroquinolone prophylaxis.
Materials and Methods: A prospective, multicenter study was conducted in Korea from January to December 2015. Prostate biopsies performed with fluoroquinolone prophylaxis during 3 months in each center were included. A pre-biopsy questionnaire was used for identification of patient characteristics. Clinical variables including underlying disease, antibiotic prophylaxis, enema, povidoneiodine cleansing of the rectum, and infectious complications were evaluated. The primary outcome was the post-biopsy infection rate after fluoroquinolone prophylaxis. Univariable and multivariable analyses were used for identification of risk factors for infectious complications.
Results: The study included 827 patients, of whom 93 patients (11.2%) reported receiving antibiotics in the previous 6 months and 2.5% had a history of prostatitis. The infectious complication rate was 2.2%. Post-biopsy sepsis was reported in 2 patients (0.2%). In multivariable analysis predictors of post-biopsy sepsis included person performing biopsy (adjusted odds ratio [OR], 4.05; 95% confidence interval [CI], 1.31-12.5; p=0.015) and operation history within 6 months (adjusted OR, 5.65; 95% CI, 1.74-18.2; p=0.004).
Conclusions: The post-prostate biopsy infectious complication rate in this study was 2.2%. Person performing biopsy (non-urologists) and recent operation history were independent risk factors for infectious complications after trans-rectal prostate biopsy.
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KEYWORD
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Biopsy, Escherichia coli, Fluoroquinolones, Infection, Prostate
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